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Syllabus 2019-20 - 10213003 - Clinical Biochemistry and Clinical Analyses (Bioquímica clínica y análisis clínicos)

Caption
  • Level 1: Tutorial support sessions, materials and exams in this language
  • Level 2: Tutorial support sessions, materials, exams and seminars in this language
  • Level 3: Tutorial support sessions, materials, exams, seminars and regular lectures in this language
DEGREE: Grado en Biología
FACULTY: FACULTY OF EXPERIMENTAL SCIENCES

ACADEMIC YEAR: 2019-20
SYLLABUS
1. COURSE BASIC INFORMATION
NAME: Clinical Biochemistry and Clinical Analyses
CODE: 10213003 ACADEMIC YEAR: 2019-20
LANGUAGE: English LEVEL: 1
ECTS CREDITS: 6.0 YEAR: 4 SEMESTER: SC
 
2. LECTURER BASIC INFORMATION
NAME: MARTÍNEZ LARA, ESTHER DEL PILAR
DEPARTMENT: U103 - BIOLOGÍA EXPERIMENTAL
FIELD OF STUDY: 060 - BIOQUÍMICA Y BIOLOGÍA MOLECULAR
OFFICE NO.: B3 - 357 E-MAIL: elara@ujaen.es P: 953212766
WEBSITE: https://www.uja.es/investigacion-y-transferencia/grupos-de-investigacion/estres-celular-y-edad
LANGUAGE: - LEVEL: 1
 
NAME: CARRERAS EGAÑA, ALFONSO MARÍA
DEPARTMENT: U103 - BIOLOGÍA EXPERIMENTAL
FIELD OF STUDY: 060 - BIOQUÍMICA Y BIOLOGÍA MOLECULAR
OFFICE NO.: B3 - B3-349 E-MAIL: acarrera@ujaen.es P: 953212765
WEBSITE: http://www4.ujaen.es/~acarrera
LANGUAGE: - LEVEL: 1
 
3. CONTENT DESCRIPTION

Teoric curriculum:

 

  1. Introduction. Biochemistry and disease.
  2. Laboratory of clinical biochemistry: Biochemical magnitudes. Prenalytical, analytical and postanalytical phases of the clinical analysis. Quality assessment.
  3. Plasma proteins. Concept and functions. Methods of detection, quantification and identification. Electrophoretic patterns in disease.
  4. Clinical enzymology. Plasma enzymes. Factors affecting enzyme levels in plasma. Enzymes of diagnostic value. The enzymes in therapy.
  5. Lipoproteins. Concept, structure and classification. Apoproteins. Lipoprotein metabolism. Disorders of lipoprotein metabolism. Procedures for the study of dyslipidemia. Atherogenesis.
  6. Electrolyte and Acid-Base Disorders. Body water compartments. Regulation of water and electrolyte homeostasis. Disorders of sodium metabolism. Disorders of potasium metabolism. Acid-Base balance. The physiological role of hydrogen ions. Hydrogen ion homeostasis: the body buffer systems. Metabolic and respiratory acid-base disorders. Assessment parameters.
  7. Renal function. Biochemical tests of renal function: urinalysis, measurement of glomerular function, analysis of renal tubular function.
  8. Liver function analysis. Hepatic functions. Biochemical tests of liver function.
  9. Disorders of carbohydrate metabolism. Glucose homeostasis. Diabetes mellitus: pathophysiology and clinical features, diagnosis, monitoring treatment. Hypoglycemia. Inborn errors of carbohydrate metabolism.
  10. Biochemistry of pregnancy. Diagnosis and monitoring of pregnancy . Screening for fetal malformation.
  11. Biochemistry of cancer. The biological basis of cancer. Tumour markers: definition, applications, clinically useful tumour markers.

 

Laboratory practice:

  1. Laboratory of clinical analysis. Guided visit to the Clinical Analysis Unit of the Complejo Hospitalario de Jaén". 
  2. Analysis of plasma proteíns: electrophoresis and ELISA.
  3. Study of lipid profile and glucose level in serum.
  4. Laboratory test for liver function analysis: enzymes and bilirubin.
  5. Renal function analysis: creatinine, urea and uric acid in serum. Urinalysis. Dispstick testing.

4. COURSE DESCRIPTION AND TEACHING METHODOLOGY

  1. a) Academic sessions to the great group of students: 26 hours (2,6 ECTS). The teaching materials can be found on the Virtual Campus.
  2. b) Academic sessions to the small group of students: 32 hours (3,2 ECTS).

Laboratory practices. Practical sessions related to the concepts explained in the theory classes will be performed. A detailed protocol will be available on the web platform Ilias, which explains the basis of the practice, and indicate the process that students must follow on their own to get the proposed objective. The results will be analysed and discuss in order to prepare a final report.

Seminars: Problem-based learning (PBL). Clinical cases, including clinical manifestations and laboratory findings, will be analysed and discuss in order to propose a diagnosis.

Students with special educational needs should contact the Student Attention Service (Servicio de Atención y Ayudas al Estudiante) in order to receive the appropriate academic support

5. ASSESSMENT METHODOLOGY

Theoric curriculum: The concepts adquired and its application to solve cases will be assess by a written exam (60%)

Seminars: Clinical cases solving and oral presentation in group or individually will be evaluated (25%)

Laboratory practices: The attendance, attitude and interest, and the quality of the laboratory report will be considered (15%)

6. BOOKLIST
MAIN BOOKLIST:
  • Medical biochemistry. Edition: 3rd ed. Author: Baynes, John. Publisher: London : Mosby, 2009  (Library)
  • Clinical Biochemistry: An Illustrated Colour Text. Edition: 6ª. Author: Murphy. Publisher: Elsevier
  • Clinical chemistry. Edition: 6th ed.. Author: Marshall, William J.. Publisher: Edinburgh ; New York : Mosby, 2008  (Library)